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Short-term outcome of cardiac resynchronization carried out at the Madras Medical Mission, India
Kelechukwu Uwanuruochi1, Anita Ganasekar2, Benjamin Solomon3, Ravi Kumar Murugesan3, Jaishankar Krishnamoorthy4, Ulhas M Pandurangi4
1 Department of Medicine, Federal Medical Centre, Umuahia, Nigeria; Department of Cardiac Electrophysiology, Institute of Cardio-Vascular Diseases, Madras Medical Mission, Chennai, Tamil Nadu, India
2 Department of Cardiac Electrophysiology, Institute of Cardio-Vascular Diseases, Madras Medical Mission, Chennai, Tamil Nadu, India
3 Cardiac Catheterization Laboratory, Institute of Cardio-Vascular Diseases, Madras Medical Mission, Chennai, Tamil Nadu, India
4 Department of Cardiology, Institute of Cardio-Vascular Diseases, Madras Medical Mission, Chennai, Tamil Nadu, India
Correspondence Address:
Kelechukwu Uwanuruochi
Department of Medicine, Federal Medical Centre, Umuahia, PMB 7001, Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0189-7969.142110
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Background: Cardiac resynchronization therapy (CRT) is a relatively new therapy for patients with symptomatic heart failure resulting from systolic dysfunction. The procedure is carried out regularly in the Cardiac Catheterization laboratory of Madras Medical Mission, India.
Objective: We sought to determine the benefit of cardiac resynchronization therapy in patients followed up at the centre.
Methods: We retrospectively studied cases of cardiac resynchronization therapy carried out at the Madras Medical Mission over the past five years with respect to clinical as well as echocardiographic changes from the time of implantation to follow-up.
Results: After a mean interval of 11.32 ± 9.25 months the improvements were observed as follows: Mean heart rate 77.94 ± 16.58/min to 69.13 ± 8.37/min (P = 0.066), mean systolic blood pressure 121.13 ± 16.33 mmHg to 131.73 ± 16.85 mmHg (P = 0.022), mean NYHA class, 3.27 ± 0.57 to 1.69 ± 0.67 (P = 0.000), QRS duration 169.39 ± 0.17 ms to 125.40 ± 24.40 ms (P = 0.000), mean ejection fraction 27.56 ± 5.47 to 38.62 ± 8.91 (P = 0.000), mean septal to posterior wall delay 164.30 ± 106.03 ms to 78.13 ± 38.04 ms (P = 0.001), mean interventricular delay 44.47 ± 23.47 ms to 26.72 ± 16.87 ms (P = 0.006), mean mitral regurgitation grade 2.50 ± 0.98 to 1.88 ± 0.90 (P = 0.026) and mean systolic dysfunction grade 3.96 ± 0.20 to 3.31 ± 0.97 (P = 0.001).
Conclusion: The improvements in mean NYHA class, ejection fraction and synchrony, at follow-up, were highly significant. |
