| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 13
| Issue : 2 | Page : 93-97 |
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Orchidectomy reduces blood pressure, but testosterone increases it in intact and orchidectomized normotensive rats
Fati O Aliyu1, Abdullateef I Alagbonsi2, Ali AU Dikko3
1 Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
2 Department of Standards and Quality Assurance, National Health Insurance, Scheme, North Central A Zonal Office, Kwara State Ministry of Health Premises, Fate; Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria
3 Department of Physiology, Faculty of Medicine, Bayero University, Kano, Kano State, Nigeria
Correspondence Address:
Abdullateef I Alagbonsi
Department of Standards and Quality Assurance, National Health Insurance Scheme, North Central A Zonal Office, Kwara State Ministry of Health Premises, Fate, Ilorin, Kwara
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0189-7969.187705
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Background: The cardioprotective effect of estrogen has been well documented, and the effect of testosterone on blood pressure (BP) is controversial and remains inconclusive.
Aim: The present study is aimed at investigating the effect of testosterone on BP in normotensive rats.
Materials and Methods: In a blind study, 30 male albino rats (200-250 g) were divided into 5 oral treatment groups (n = 6 rats each) as follows: Groups I and II were intact rats that received 1 ml/kg normal saline (vehicle) and 25 mg/kg testosterone subcutaneously for 24 days. Group III was sham-operated and received normal saline for 24 days. Groups IV and V were bilaterally orchidectomized and received normal saline and 25 mg/kg testosterone subcutaneously for 24 days.
Results: The systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP) of the sham-operated rats that received normal saline were not significantly different from the intact (control) rats that received normal saline (P > 0.05). Testosterone treatment in control rats caused a sustainably higher SBP (P < 0.001), DBP (P < 0.001), PP (P < 0.001), and MAP (P < 0.001) when compared to control that received normal saline. The SBP (P < 0.01), DBP (P < 0.001), MAP (P < 0.001), but not PP (P > 0.05) was significantly reduced in orchidectomized rats that received normal saline when compared to control. However, administration of testosterone in orchidectomized rats abolished orchidectomy-induced reduction in SBP, DBP, MAP, but not PP and further increased them above the control level (P < 0.05).
Conclusion: This study shows that testosterone is prohypertensive in normotensive rats. |
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