• Users Online: 840
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 15  |  Issue : 2  |  Page : 98-101

Consanguineous marriage makes congenital heart diseases more complex

1 Department of Cardiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
2 Department of Statistics, Utkal University, Bhubaneswar, Odisha, India
3 Mother's Public School, Bhubaneswar, Odisha, India

Correspondence Address:
Dr. Ramachandra Barik
All India Institute of Medical Sciences, Bhubaneswar - 751 019, Odisha
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njc.njc_40_17

Rights and Permissions

Introduction: Inbreeding increases homozygotes for autosomal recessive disorders resulting in high prevalence of congenital heart disease (CHD). This cross-section looks whether consanguineous marriage (CM) makes CHDs more complex. Subjects and Methods: This was an observational study which looked at the cross-section of a cohort of consecutive 113 patients having different CHD who visited Nizam Institute of Medical Sciences, Andhra Pradesh, during the year 2016 for surgery or intervention. The definitive diagnosis of CHD was supported by clinical profile, chest X-ray, echo, ultrasound abdomen, and cardiac catheterization which is appropriate. The study population was divided into CM group and distance marriage (DM) group. The categorical variables were analyzed using descriptive statistics. Results: Out of 113 patients with CHD, 61 (54%) were females. A majority 104 (94%) were Hindu. About 74% of patients were from below poverty line category. Approximately 27% and 73% patients were born out of consanguineous and DM, respectively. Most of the patients were from a rural background, and 63.7% had an education level of ≤10th class. Approximately, a total of 50 (44.2%) patients had complex CHDs (CCHDs). CCHD had significant association with CM (odds ratio: 2.60 95% confidence interval: 1.11–6.09, and P = 0.02). Conclusion: As there was a significant association of CCHD with inbreed marriage, this observation discourages CM.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded210    
    Comments [Add]    

Recommend this journal