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ORIGINAL ARTICLE
Year : 2021  |  Volume : 18  |  Issue : 1  |  Page : 14-21

Association of total lymphocyte count and echocardiographic parameters in human immunodeficiency virus-positive patients


1 Cardiology Unit, Department of Internal Medicine, Federal Medical Centre, Yenagoa, Bayelsa State, Nigeria
2 Department of Experimental Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria

Correspondence Address:
Dr. Abaram Chesa Mankwe
Cardiology Unit, Department of Internal Medicine, Federal Medical Centre, Yenagoa, Bayelsa State
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njc.njc_38_20

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Background: The pathophysiology of cardiovascular diseases in HIV infection has been linked to chronic inflammation that precipitates atherosclerosis and low lymphocyte count is a common finding during the systemic inflammatory response. Aim: The aim of this study is to evaluate the relationship between total lymphocyte count (TLC) and echocardiographic parameters in HIV positive subjects. Method: TLC of 100 HAART naïve newly diagnosed HIV/AIDS subjects, recruited from a Nigerian Tertiary Health Institution were analyzed, and their left ventricular (LV) function and geometry were evaluated using transthoracic echocardiography. Results: Abnormalities in LV function and geometry were observed in the HIV seropositive subjects and their TLCs were lower in those with severe forms of abnormalities. Conclusion: Concluding, TLC is inversely associated with LV dysfunction or abnormal geometry.


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