Year : 2019 | Volume
: 16 | Issue : 2 | Page : 93--97
Lipid and apoprotein markers and carotid intima-media thickness among hypertensive Nigerians
Modupe Akinrele Kuti1, Abiodun Moshood Adeoye2, Samuel Ayodeji Agboola1, Tolulope Olutosin Omilakin3
1 Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria
2 Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
3 Department of Ophthalmology, Eleta Eye Institute, Ibadan, Nigeria
Context: Measurement of lipids and apoproteins are essential components aimed at reducing the global burden of atherosclerotic cardiovascular disease. Carotid intima-media thickness (CIMT) has been widely accepted as an index of subclinical atherosclerosis. A relationship between CIMT and the parameters of the traditional lipid profile has been described.
Aim: Evaluation of the diagnostic character of lipid and apoprotein markers, which are cheap and easy to perform, in detecting a significant thickening of the carotid intima media in hypertensive persons.
Subjects and Methods: Cross-sectional study of adult male hypertensive persons with fasting measurement of the traditional lipid profile and apoprotein B. CIMT of the common carotid artery was determined by ultrasound in all participants.
Results: The mean CIMT was significantly higher among the hypertensive participants than normotensive controls. Age, systolic blood pressure, triglycerides, low-density lipoprotein-cholesterol (LDL-C), and Apo B were all significantly associated with CIMT. Hypertensive persons with CIMT ≥1.00 mm had significantly higher serum concentrations of total cholesterol (TC), LDL-C, and Apo B. The positive predictive value of a result (TC >200 mg/dL, LDL-C >130 mg/dL, and Apo B >100 mg/dL) was <50%, while that for a negative result (TC <200 mg/dL, LDL-C <130 mg/dL, and Apo B <100 mg/dL) approached or was equal to 100%.
Conclusions: There is some relationship between dyslipidemia and significant thickness of the carotid intima media. The levels of TC, LDL-C, and Apo B in plasma, which are cheaper and easier to determine, may help in the selection of hypertensive persons to be offered CIMT assessment.
Dr. Modupe Akinrele Kuti
Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan
|How to cite this article:|
Kuti MA, Adeoye AM, Agboola SA, Omilakin TO. Lipid and apoprotein markers and carotid intima-media thickness among hypertensive Nigerians.Nig J Cardiol 2019;16:93-97
|How to cite this URL:|
Kuti MA, Adeoye AM, Agboola SA, Omilakin TO. Lipid and apoprotein markers and carotid intima-media thickness among hypertensive Nigerians. Nig J Cardiol [serial online] 2019 [cited 2023 Mar 23 ];16:93-97
Available from: https://www.nigjcardiol.org/article.asp?issn=0189-7969;year=2019;volume=16;issue=2;spage=93;epage=97;aulast=Kuti;type=0